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Who We Are

The A.P.E. Health Group (Anthropogenic Pathogen Emergence) is a transdisciplinary research lab dedicated to investigating how human-driven environmental changes alter the ecology and evolution of zoonotic viruses. Our mission is to close the critical gaps in our understanding of disease emergence at newly created forest edges and provide scientifically backed guidance for mitigating pandemic risk.

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Our Mission

To discover what nature has already solved.
We aim to move beyond reactive responses to outbreaks toward a proactive understanding of disease resilience. By treating our closest living relatives as partners in our quest for knowledge, we work to uncover the biological mechanisms that allow certain species to live in harmony with the world’s most dangerous pathogens. We generate data-driven models to predict high-risk systems for disease emergence and provide scientifically backed guidance for pandemic mitigation.

Themes In Our Work

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We investigate how landscape change and intensified human-wildlife interactions at the forest edge facilitate virus adaptation and cross-species pathogen transmission across ecosystems.

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We examine lifetime cumulative antigenic exposure to determine if exposure to viral homologs acts as a natural immunogen, priming the immune system to withstand lethal pathogens.

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We utilize the high genetic similarity between eastern gorillas and humans to identify biologically similar targets for viral spillover and uncover unique innate immune responses in our closest relatives.

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A Global Approach

Our research is built on equitable collaboration, integrating expertise from 50+ scientists across Uganda, Rwanda, DR Congo, Myanmar, and Peru. We are committed to building local research capacity and mentoring the next generation of U.S. and national scientists to lead global health efforts.

Partners

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